Article
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.
Cancer research - 15 Mar 2006
Colombo Emanuela, Martinelli Paola, Zamponi Raffaella, Shing Danielle C, Bonetti Paola, Luzi Lucilla, Volorio Sara, Bernard Loris, Pruneri Giancarlo, Alcalay Myriam, Pelicci Pier Giuseppe
Abstract excerpt
One third of acute myeloid leukemias (AMLs) are characterized by the aberrant cytoplasmic localization of nucleophosmin (NPM) due to mutations within its putative nucleolar localization signal. NPM mutations are mutually exclusive with major AML-associated chromosome rearrangements and are frequently associated with a normal karyotype, suggesting that they are critical during leukemogenesis. The underlying...
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