Article
Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007
Liu Xia, Liu Zhixue, Jang Sung-Wuk, Ma Zhiyong, Shinmura Kazuya, Kang Sumin, Dong Shaozhong, Chen Jing, Fukasawa Kenji, Ye Keqiang
Abstract excerpt
Nucleophosmin/B23 is a major multifunctional nucleolar phosphoprotein that plays a critical role in ribosome biogenesis and cell proliferation. Arf tumor suppressor binds B23 and enhances its sumoylation. However, the biological effects of this event remain unknown. Here we show that B23 is sumoylated on both Lysine 230 and 263 residues, but the latter is the major one. Mutation of K263, but not K230, into R...
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