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Article

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.

Nature cell biology - 1 Aug 2005

Wang Wei, Budhu Anuradha, Forgues Marshonna, Wang Xin Wei

Abstract excerpt

Centrosome duplication is tightly controlled during faithful cell division, and unnecessary reduplication can lead to supernumerary centrosomes and multipolar spindles that are associated with most human cancer cells. In addition to nucleocytoplasmic transport, the Ran-Crm1 network is involved in regulating centrosome duplication to ensure the formation of a bipolar spindle. Here, we discover that nucleophosmin...

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PMID: 16041368
DOI: 10.1038/ncb1282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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