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Article

Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.

Molecular and cellular biology - 1 Feb 2004

Bertwistle David, Sugimoto Masataka, Sherr Charles J

Abstract excerpt

The Arf tumor suppressor inhibits cell cycle progression through both p53-dependent and p53-independent mechanisms, including interference with rRNA processing. Using tandem-affinity-tagged p19(Arf), we purified Arf-associated proteins from mouse NIH 3T3 fibroblasts undergoing cell cycle arrest. Tagged p19(Arf) associated with nucleolar and ribosomal proteins, including nucleophosmin/B23 (NPM), a protein thought...

Topics

Animals
Cyclin-Dependent Kinase Inhibitor p16
Genes, Reporter
Mice
Mutation
NIH 3T3 Cells
Nuclear Proteins
Nucleophosmin
Protein Binding
RNA, Ribosomal
Ribosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transfection

Tumor Suppressor Protein p14ARF

Source

Open in PubMed Open full text

Identifiers

PMID: 14729947
DOI: 10.1128/MCB.24.3.985-996.2004
PMCID: PMC321449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-14729947-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Physical and functional interactions of the Arf tumor suppressor protein with nucleophosmin/B23.PMID 14729947Read ↗

Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex.Semantic proximity Read ↗

B23 and ARF: friends or foes?Semantic proximity Read ↗

Nucleolar Arf tumor suppressor inhibits ribosomal RNA processing.Semantic proximity Read ↗

Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor ProteinSemantic proximity Read ↗

Small mitochondrial Arf (smArf) protein corrects p53-independent developmental defects of Arf tumor suppressor-deficient mice.Semantic proximity Read ↗

DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARFSemantic proximity Read ↗

Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant.Semantic proximity Read ↗

N-terminal polyubiquitination and degradation of the Arf tumor suppressor.Semantic proximity Read ↗

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2Semantic proximity Read ↗

Sumoylation induced by the Arf tumor suppressor: a p53-independent function.Semantic proximity Read ↗

Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3Semantic proximity Read ↗

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin RemodelingSemantic proximity Read ↗

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