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Article

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.

Molecular and cellular biology - 1 Dec 2008

Maggi Leonard B, Kuchenruether Michael, Dadey David Y A, Schwope Rachel M, Grisendi Silvia, Townsend R Reid, Pandolfi Pier Paolo, Weber Jason D

Abstract excerpt

Nucleophosmin (NPM) (B23) is an essential protein in mouse development and cell growth; however, it has been assigned numerous roles in very diverse cellular processes. Here, we present a unified mechanism for NPM's role in cell growth; NPM directs the nuclear export of both 40S and 60S ribosomal subunits. NPM interacts with rRNA and large and small ribosomal subunit proteins and also colocalizes with large and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18809582
DOI: 10.1128/MCB.01548-07
PMCID: PMC2593371

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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