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Article

A trophic role for Wnt-Ror kinase signaling during developmental pruning in Caenorhabditis elegans.

Nature neuroscience - 1 Aug 2009

Hayashi Yu, Hirotsu Takaaki, Iwata Ryo, Kage-Nakadai Eriko, Kunitomo Hirofumi, Ishihara Takeshi, Iino Yuichi, Kubo Takeo

Abstract excerpt

The molecular mechanism by which neurites are selected for elimination or incorporation into the mature circuit during developmental pruning remains unknown. The trophic theory postulates that local cues provided by target or surrounding cells act to inhibit neurite elimination. However, no widely conserved factor mediating this trophic function has been identified. We found that the developmental survival of...

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PMID: 19561603
DOI: 10.1038/nn.2347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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