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Article

The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans.

Development (Cambridge, England) - 1 Feb 2014

Moffat Laura L, Robinson Ryan E, Bakoulis Anastasia, Clark Scott G

Abstract excerpt

Wnts control a wide range of essential developmental processes, including cell fate specification, axon guidance and anteroposterior neuronal polarization. We identified a conserved transmembrane RING finger protein, PLR-1, that governs the response to Wnts by lowering cell-surface levels of the Frizzled family of Wnt receptors in Caenorhabditis elegans. Loss of PLR-1 activity in the neuron AVG causes its...

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Identifiers

PMID: 24401370
DOI: 10.1242/dev.101600
PMCID: PMC3899816

Genes

RNF43
ZNRF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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