LIN-44/Wnt controls developmental neurite pruning via UNC-43/CaMKII and PKC-2/PKC in C. elegans

Abstract excerpt

During development, many neurons prune their neurites. While many pruning events are activity-dependent, some neurons undergo stereotyped and developmentally regulated neurite pruning, and our understanding of the signaling pathways that mediate this form of pruning remains limited. In this study, using the PDB motor neuron in C. elegans, we show that the Wnt-calcium signaling pathway is required for stereotyped n...

Topics

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• Caenorhabditis elegans Proteins
• Nerve Growth Factors
• Nervous System
• Neurites
• Neurogenesis
• Receptor Protein-Tyrosine Kinases
• Receptor Tyrosine Kinase-like Orphan Receptors
• Wnt1 Protein

Identifiers and source

Literature Corpus work

f416432a-1e7a-577f-95bf-fbb95a7761a1

DOI

10.64898/2026.06.04.729963