Article
MBR-1, a novel helix-turn-helix transcription factor, is required for pruning excessive neurites in Caenorhabditis elegans.
Current biology : CB - 6 Sept 2005
Kage Eriko, Hayashi Yu, Takeuchi Hideaki, Hirotsu Takaaki, Kunitomo Hirofumi, Inoue Takao, Arai Hiroyuki, Iino Yuichi, Kubo Takeo
Abstract excerpt
In the developing brain, excessive neurites are actively pruned in the construction and remodeling of neural circuits. We demonstrate for the first time that the pruning of neurites occurs in the simple neural circuit of Caenorhabditis elegans and that a novel transcription factor, MBR-1, is involved in this process. We identified MBR-1 as a C. elegans ortholog of Mblk-1, a transcription factor that is expressed...
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