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Article

A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans.

PloS one - 1 Jan 2016

Carr David, Sanchez-Alvarez Leticia, Imai Janice H, Slatculescu Cristina, Noblett Nathaniel, Mao Lei, Beese Lorena, Colavita Antonio

Abstract excerpt

Genetic pathways that regulate nascent neurite formation play a critical role in neuronal morphogenesis. The core planar cell polarity components VANG-1/Van Gogh and PRKL-1/Prickle are involved in blocking inappropriate neurite formation in a subset of motor neurons in C. elegans. A genetic screen for mutants that display supernumerary neurites was performed to identify additional factors involved in this...

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PMID: 27300162
DOI: 10.1371/journal.pone.0157537
PMCID: PMC4907426

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Source receipt: pubmed, retrieved 7 Sept 2026.

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