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Article

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.

Brain research - 25 Aug 2009

Liang Yideng, Jiang Haibing, Ratovitski Tamara, Jie Chunfa, Nakamura Masayuki, Hirschhorn Ricky R, Wang Xiaofang, Smith Wanli W, Hai Tsonwin, Poirier Michelle A, Ross Christopher A

Abstract excerpt

Huntington's disease is a progressive neurodegenerative disorder caused by a polyglutamine expansion near the N-terminus of huntingtin. The mechanisms of polyglutamine neurotoxicity, and cellular responses are not fully understood. We have studied gene expression profiles by short oligo array using an inducible PC12 cell model expressing an N-terminal huntingtin fragment with expanded polyglutamine...

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Identifiers

PMID: 19559011
DOI: 10.1016/j.brainres.2009.06.049
PMCID: PMC2765721

Genes

ATF3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.PMID 19559011Read ↗

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