Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.

Journal of molecular neuroscience : MN - 1 Oct 2011

Illuzzi Jennifer L, Vickers Cassie A, Kmiec Eric B

Abstract excerpt

Huntington's disease (HD) occurs through an expansion of the trinucleotide repeat in the HD gene resulting in the lengthening of the polyglutamine stretch within the N terminus of the protein, huntingtin (Htt). While the function of the protein is still being fully elucidated, we have shown that genomic DNA damage is associated with the expression of mutant Htt (mHtt) in a time-dependent fashion. With the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Damage
Share to HEK293 Cells
Share to Huntingtin Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Huntington Disease

Share to Peptide Fragments

Share to Recombinant Fusion Proteins

Share to Tumor Suppressor Protein p53

Share to Ubiquitination

Source

Identifiers

PMID: 21465263
DOI: 10.1007/s12031-011-9516-4

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.PMID 21465263Read ↗

Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons.Semantic proximity Read ↗

p53 tumor suppressor protein regulates the levels of huntingtin gene expression.Semantic proximity Read ↗

Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.Semantic proximity Read ↗

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathwaysSemantic proximity Read ↗

Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.Semantic proximity Read ↗

Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.Semantic proximity Read ↗

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.Semantic proximity Read ↗

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.Semantic proximity Read ↗

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53Semantic proximity Read ↗

Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis.Semantic proximity Read ↗

Oxidative stress promotes mutant huntingtin aggregation and mutant huntingtin-dependent cell death by mimicking proteasomal malfunction.Semantic proximity Read ↗

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.