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Article

Sp1 regulates human huntingtin gene expression.

Journal of molecular neuroscience : MN - 1 Jun 2012

Wang Ruitao, Luo Yawen, Ly Philip T T, Cai Fang, Zhou Weihui, Zou Haiyan, Song Weihong

Abstract excerpt

Huntington's disease (HD) is a hereditary neurodegenerative disorder resulting from the expansion of a polyglutamine tract in the huntingtin protein. The expansion of cytosine-adenine-guanine repeats results in neuronal loss in the striatum and cortex. Mutant huntingtin (HTT) may cause toxicity via a range of different mechanisms. Recent studies indicate that impairment of wild-type HTT function may also...

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Source

Identifiers

PMID: 22399227
DOI: 10.1007/s12031-012-9739-z

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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