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Article

Protein tyrosine phosphatases are up-regulated and participate in cell death induced by polyglutamine expansion.

The Journal of biological chemistry - 15 Nov 2002

Wu Zhi-Liang, O'Kane Teresa M, Scott Richard W, Savage Mary J, Bozyczko-Coyne Donna

Abstract excerpt

Polyglutamine expansion is the cause of several neurodegenerative diseases. An in vitro model of polyglutamine-induced neuronal cell death was developed using truncated mutant huntingtin (Htt) and PC12 cells. Cell death was specifically observed in cells expressing a truncated mutant huntingtin-g...

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Identifiers

PMID: 12226089
DOI: 10.1074/jbc.M206890200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12226089-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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