Article
Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.
Human molecular genetics - 15 Jan 2006
Apostol Barbara L, Illes Katalin, Pallos Judit, Bodai Laszlo, Wu Jun, Strand Andrew, Schweitzer Erik S, Olson James M, Kazantsev Aleksey, Marsh J Lawrence, Thompson Leslie Michels
Abstract excerpt
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by an expanded polyglutamine (polyQ) tract within the huntingtin protein (Htt). Identifying the pathways that are altered in response to the mutant protein is crucial for understanding the cellular processes impacted by the disease as well as for the rational development of effective pharmacological interventions. Here, expression...
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