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Article

Interaction of Huntington disease protein with transcriptional activator Sp1.

Molecular and cellular biology - 1 Mar 2002

Li Shi-Hua, Cheng Anna L, Zhou Hui, Lam Suzanne, Rao Manjula, Li He, Li Xiao-Jiang

Abstract excerpt

Polyglutamine expansion causes Huntington disease (HD) and at least seven other neurodegenerative diseases. In HD, N-terminal fragments of huntingtin with an expanded glutamine tract are able to aggregate and accumulate in the nucleus. Although intranuclear huntingtin affects the expression of numerous genes, the mechanism of this nuclear effect is unknown. Here we report that huntingtin interacts with Sp1, a...

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Identifiers

PMID: 11839795
DOI: 10.1128/MCB.22.5.1277-1287.2002
PMCID: PMC134707

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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