Article
Dynamic expression of Hsp27 in the presence of mutant ataxin-3.
Biochemical and biophysical research communications - 14 Oct 2005
Chang Wei-Hsiu, Cemal Cemal K, Hsu Yung-Hsiang, Kuo Cheng-Liang, Nukina Nobuyuki, Chang Ming-Hong, Hu Hsiao-Tang, Li Chuan, Hsieh Mingli
Abstract excerpt
Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant spinocerebellar degeneration characterized by a wide range of clinical manifestations. The molecular mechanisms underlying the selective neuronal death typical of MJD/SCA3 are unknown. In this study, human SK-N-SH neuroblastoma cells stably transfected with full-length MJD with 78 CAG repeats were assayed for the dynamic...
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