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Article

A novel pathway for transcriptional regulation of α‐synuclein

13 Dec 2006

Abstract excerpt

Alpha-synuclein is an abundant neuronal protein that has been linked to both normal synaptic function and neurodegeneration--in particular, Parkinson's disease (PD). Uncovering mechanisms that control alpha-synuclein transcription is therefore critical for PD pathogenesis and synaptic function. We previously reported that in PC12 cells and primary neurons, alpha-synuclein is transcriptionally up-regulated after...

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PMID: 17167067
DOI: 10.1096/fj.06-7111com

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