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Article

The val158met polymorphism of human catechol-O-methyltransferase (COMT) affects anterior cingulate cortex activation in response to painful laser stimulation.

Molecular pain - 31 May 2010

Mobascher Arian, Brinkmeyer Juergen, Thiele Holger, Toliat Mohammad R, Steffens Michael, Warbrick Tracy, Musso Francesco, Wittsack Hans-Joerg, Saleh Andreas, Schnitzler Alfons, Winterer Georg

Abstract excerpt

BACKGROUND: Pain is a complex experience with sensory, emotional and cognitive aspects. Genetic and environmental factors contribute to pain-related phenotypes such as chronic pain states. Genetic variations in the gene coding for catechol-O-methyltransferase (COMT) have been suggested to affect clinical and experimental pain-related phenotypes including regional mu-opioid system responses to painful stimulation...

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Identifiers

PMID: 20509977
DOI: 10.1186/1744-8069-6-32
PMCID: PMC2887789

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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