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Article

Generation of a mouse model for arginase II deficiency by targeted disruption of the arginase II gene.

Molecular and cellular biology - 1 Feb 2001

Shi O, Morris S M, Zoghbi H, Porter C W, O'Brien W E

Abstract excerpt

Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of...

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Identifiers

PMID: 11154268
DOI: 10.1128/MCB.21.3.811-813.2001
PMCID: PMC86672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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