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Article

Failures in mitochondrial tRNAMet and tRNAGln metabolism caused by the novel 4401A>G mutation are involved in essential hypertension in a Han Chinese Family.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2009

Li Ronghua, Liu Yuqi, Li Zongbin, Yang Li, Wang Shiwen, Guan Min-Xin

Abstract excerpt

We report here on the clinical, genetic, and molecular characterization of 1 Han Chinese family with maternally transmitted hypertension. Three of 7 matrilineal relatives in this 4-generation family exhibited the variable degree of essential hypertension at the age at onset, ranging from 35 to 60 years old. Sequence analysis of the complete mitochondrial DNA in this pedigree identified the novel homoplasmic...

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Identifiers

PMID: 19546379
DOI: 10.1161/HYPERTENSIONAHA.109.129270
PMCID: PMC2907155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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