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Maternally Inherited Essential Hypertension Is Associated With the Novel 4263A>G Mutation in the Mitochondrial tRNA <sup>Ile</sup> Gene in a Large Han Chinese Family

31 Mar 2011

Abstract excerpt

RATIONALE: Despite maternal transmission of hypertension in some pedigrees, pathophysiology of maternally inherited hypertension remains poorly understood. OBJECTIVE: To establish a causative link between mitochondrial dysfunction and essential hypertension. METHOD AND RESULTS: A total of 106 subjects from a large Chinese family underwent clinical, genetic, molecular, and biochemical evaluations. Fifteen of 24...

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PMID: 21454794
DOI: 10.1161/circresaha.110.231811

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