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Article

The tRNAMet 4435A>G mutation in the mitochondrial haplogroup G2a1 is responsible for maternally inherited hypertension in a Chinese pedigree.

European journal of human genetics : EJHG - 1 Nov 2011

Lu Zhongqiu, Chen Hong, Meng Yanzi, Wang Yan, Xue Ling, Zhi Shaoce, Qiu Qiaomeng, Yang Li, Mo Jun Qin, Guan Min-Xin

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) have been associated with hypertension in several pedigrees with maternal inheritance. However, the pathophysiology of maternally inherited hypertension remains poorly understood. We reported here clinical, genetic evaluations and molecular analysis of mtDNA in a three-generation Han Chinese family with essential hypertension. Eight of 17 matrilineal relatives exhibited a...

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Identifiers

PMID: 21694735
DOI: 10.1038/ejhg.2011.111
PMCID: PMC3198143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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