Article
Mitochondrial transfer RNAMet 4435A>G mutation is associated with maternally inherited hypertension in a Chinese pedigree.
Hypertension (Dallas, Tex. : 1979) - 1 Jun 2009
Liu Yuqi, Li Ronghua, Li Zongbin, Wang Xin-Jian, Yang Li, Wang Shiwen, Guan Min-Xin
Abstract excerpt
Mitochondrial DNA mutations have been associated with cardiovascular disease. We report here the clinical, genetic, and molecular characterization of 1 Han Chinese family with suggestively maternally transmitted hypertension. Matrilineal relatives in this family exhibited the variable degree of hypertension at the age at onset of 44 to 55 years old. Sequence analysis of entire mitochondrial DNA in this pedigree...
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