Article
The -1562C/T MMP-9 promoter polymorphism does not predict MMP-9 expression levels or invasive capacity in saphenous vein smooth muscle cells cultured from different patients.
Atherosclerosis - 1 Dec 2009
Maqbool Azhar, Turner Neil A, Galloway Stacey, Riches Kirsten, O'Regan David J, Porter Karen E
Abstract excerpt
Matrix metalloproteinase-9 (MMP-9) is an important regulator of vascular smooth muscle cell (SMC) invasion and proliferation. The T allele of the -1562C/T MMP-9 promoter polymorphism reportedly confers increased MMP-9 promoter activity, plasma MMP-9 levels and susceptibility to vascular pathologies. The aim of this study was to determine whether the MMP-9 -1562C/T polymorphism directly influences endogenous MMP-9...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.