Article
Genetic polymorphism of matrix metalloproteinase (MMP)-9 does not affect plasma MMP-9 activity in healthy subjects.
Clinica chimica acta; international journal of clinical chemistry - 1 Mar 2006
Demacq Caroline, de Souza Ana P, Machado Alcyone A, Gerlach Raquel F, Tanus-Santos Jose E
Abstract excerpt
BACKGROUND: Plasma MMP-9 levels have been shown to predict cardiovascular risk, and a functional substitution C to T at position -1562 in the promoter region of the MMP-9 gene has been associated with the severity of cardiovascular diseases. We examined the association between the C(-1562)T polymorphism and MMP-9 activity in healthy subjects. METHODS: We studied 200 healthy male white volunteers (age range: 20-55...
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