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Article

Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype.

Breast cancer research and treatment - 1 Dec 2004

Grieu Fabienne, Li Wei Qi, Iacopetta Barry

Abstract excerpt

The matrix metalloproteinases (MMPs) have been shown to play important roles in cancer progression. In this study we examined whether common genetic variants in two key MMPs are associated with phenotypic features of breast cancers and patient outcome. A single nucleotide polymorphism in the promoter region of MMP-2 (-1306 C-->T) abolishes Sp1 binding and is associated with lower transcriptional activity, while...

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Identifiers

PMID: 15609121
DOI: 10.1007/s10549-004-0595-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer phenotype.PMID 15609121Read ↗

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