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Article

Plasma concentrations and genetic variation of matrix metalloproteinase 9 and prognosis of patients with cardiovascular disease.

Circulation - 1 Apr 2003

Blankenberg Stefan, Rupprecht Hans J, Poirier Odette, Bickel Christoph, Smieja Marek, Hafner Gerd, Meyer Jürgen, Cambien François, Tiret Laurence

Abstract excerpt

BACKGROUND: Matrix metalloproteinase (MMP)-9 secretion by macrophages and other inflammatory cells accelerates atherosclerotic progression and destabilizes vulnerable plaque in animal models. However, epidemiological data evaluating the prognostic impact of circulating concentrations and functional genetic variations of MMP-9 are lacking. METHODS AND RESULTS: In a prospective study of 1127 patients with...

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PMID: 12668489
DOI: 10.1161/01.CIR.0000058700.41738.12

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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