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Influence of gelatinase B polymorphic variants and its serum levels in atherosclerosis.

Genetic testing and molecular biomarkers - 1 Aug 2012

Spurthi Kondapalli Mrudula, Galimudi Rajesh Kumar, Srilatha Gantala, Sahu Sanjib Kumar, Nallari Pratibha, Hanumanth Surekha Rani

Abstract excerpt

AIM: Atherosclerosis, the underlying pathology of cardiovascular disease, is a common, multifactorial disorder with both genetic and environmental components as risk factors. Gelatinase B, also known as MMP-9, is one of the matrix metalloproteinases that is highly expressed in the disruption-prone regions of atherosclerotic plaques. It has been hypothesized that a genetic variation affecting the expression or...

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PMID: 22809399
DOI: 10.1089/gtmb.2011.0299

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CAD

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