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Article

Polymorphisms in TGF-beta1 gene and the risk of lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2006

Kang Hyo-Gyoung, Chae Myung Hwa, Park Jung Min, Kim Eun Jin, Park Jae Hyung, Kam Sin, Cha Sung Ick, Kim Chang Ho, Park Rang-Woon, Park Sun Hee, Kim Yong Lim, Kim In-San, Jung Tae Hoon, Park Jae Yong

Abstract excerpt

BACKGROUND: Transforming growth factor-beta1 (TGF-beta1) functions as a suppressor of tumor initiation by inhibiting cellular proliferation or by promoting cellular differentiation or apoptosis in the early phase of cancer development. Variations in the DNA sequence in the TGF-beta1 gene may lead to altered TGF-beta1 production and/or activity, and so this can modulate an individual's susceptibility to lung...

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PMID: 16499994
DOI: 10.1016/j.lungcan.2005.11.016

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