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Article

DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Allen Chris, Kurimasa Akihiro, Brenneman Mark A, Chen David J, Nickoloff Jac A

Abstract excerpt

DNA-dependent protein kinase (DNA-PK), composed of Ku70, Ku80, and the catalytic subunit (DNA-PKcs), is involved in repairing double-strand breaks (DSBs) by nonhomologous end-joining (NHEJ). Certain proteins involved in NHEJ are also involved in DSB repair by homologous recombination (HR). To test the effects of DNA-PKcs on DSB-induced HR, we integrated neo direct repeat HR substrates carrying the I-SceI...

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Identifiers

PMID: 11904432
DOI: 10.1073/pnas.052545899
PMCID: PMC122597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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