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Article

DNA-PKcs Is Involved in Ig Class Switch Recombination in Human B Cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2015

Björkman Andrea, Du Likun, Felgentreff Kerstin, Rosner Cornelia, Pankaj Kamdar Radhika, Kokaraki Georgia, Matsumoto Yoshihisa, Davies E Graham, van der Burg Mirjam, Notarangelo Luigi D, Hammarström Lennart, Pan-Hammarström Qiang

Abstract excerpt

Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break repair pathways in mammalian cells and is required for both V(D)J recombination and class switch recombination (CSR), two Ig gene-diversification processes occurring during B cell development. DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) is a component of the classical NHEJ machinery and has a critical function during V(D)J...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26546606
DOI: 10.4049/jimmunol.1501633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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