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Article

Increased Resection at DSBs in G2-Phase Is a Unique Phenotype Associated with DNA-PKcs Defects That Is Not Shared by Other Factors of c-NHEJ.

Cells - 2 Jul 2022

Xiao Huaping, Li Fanghua, Mladenov Emil, Soni Aashish, Mladenova Veronika, Pan Bing, Dueva Rositsa, Stuschke Martin, Timmermann Beate, Iliakis George

Abstract excerpt

The load of DNA double-strand breaks (DSBs) induced in the genome of higher eukaryotes by different doses of ionizing radiation (IR) is a key determinant of DSB repair pathway choice, with homologous recombination (HR) and ATR substantially gaining ground at doses below 0.5 Gy. Increased resection and HR engagement with decreasing DSB-load generate a conundrum in a classical non-homologous end-joining...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35805183
DOI: 10.3390/cells11132099
PMCID: PMC9265841

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