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Article

Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins.

Molecular biology of the cell - 1 Jul 2024

Kubo Tomohiro, Sasaki Rinka, Oda Toshiyuki

Abstract excerpt

Tubulins undergo several kinds of posttranslational modifications (PTMs) including glutamylation and glycylation. The contribution of these PTMs to the motilities of cilia and flagella is still unclear. Here, we investigated the role of tubulin glycylation by examining a novel Chlamydomonas mutant lacking TTLL3, an enzyme responsible for initiating glycylation. Immunostaining of cells and flagella revealed that...

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Identifiers

PMID: 38758663
DOI: 10.1091/mbc.E24-04-0154
PMCID: PMC11244163

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Tubulin glycylation controls ciliary motility through modulation of outer-arm dyneins.PMID 38758663Read ↗

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