Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.

The Journal of biological chemistry - 1 Apr 2011

Pathak Narendra, Austin Christina A, Drummond Iain A

Abstract excerpt

Tubulin post-translational modifications generate microtubule heterogeneity and modulate microtubule function, and are catalyzed by tubulin tyrosine ligase-like (TTLL) proteins. Using antibodies specific to monoglycylated, polyglycylated, and glutamylated tubulin in whole mount immunostaining of zebrafish embryos, we observed distinct, tissue-specific patterns of tubulin modifications. Tubulin modification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axoneme
Share to Cilia
Share to Gene Knockdown Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Organ Specificity

Share to Peptide Synthases

Share to Protein Processing, Post-Translational

Share to Tubulin

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21262966
DOI: 10.1074/jbc.M110.209817
PMCID: PMC3064220

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tubulin tyrosine ligase-like genes ttll3 and ttll6 maintain zebrafish cilia structure and motility.PMID 21262966Read ↗

TTLL3 Is a tubulin glycine ligase that regulates the assembly of cilia.Semantic proximity Read ↗

The zebrafish fleer gene encodes an essential regulator of cilia tubulin polyglutamylation.Semantic proximity Read ↗

Alterations in the balance of tubulin glycylation and glutamylation in photoreceptors leads to retinal degeneration.Semantic proximity Read ↗

CEP41 is mutated in Joubert syndrome and is required for tubulin glutamylation at the cilium.Semantic proximity Read ↗

Cell context-specific effects of the beta-tubulin glycylation domain on assembly and size of microtubular organelles.Semantic proximity Read ↗

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertilitySemantic proximity Read ↗

Mutations of tubulin glycylation sites reveal cross-talk between the C termini of alpha- and beta-tubulin and affect the ciliary matrix in Tetrahymena.Semantic proximity Read ↗

Mutation of NEKL-4/NEK10 and TTLL genes suppress neuronal ciliary degeneration caused by loss of CCPP-1 deglutamylase function.Semantic proximity Read ↗

Glutamylation imbalance leads to photoreceptor cell degenerationSemantic proximity Read ↗

⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis.Semantic proximity Read ↗

Mutation of NEKL-4/NEK10 and TTLL genes opposes loss of the CCPP-1 deglutamylase and prevents neuronal ciliary degenerationSemantic proximity Read ↗

Tubulin Tyrosine Ligase–Like 1 Deficiency Results in Chronic Rhinosinusitis and Abnormal Development of Spermatid Flagella in MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.