Article
Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice.
Anticancer research - 1 Jun 2009
Nagakura Chisa, Hayashi Katsuhiro, Zhao Ming, Yamauchi Kensuke, Yamamoto Norio, Tsuchiya Hiroyuki, Tomita Katsuro, Bouvet Michael, Hoffman Robert M
Abstract excerpt
We report here a tumor-targeting strategy for pancreatic cancer using a modified auxotrophic strain of Salmonella typhimurium. The genetically-modified strain of S. typhimurium requires the amino acids arginine and leucine. These mutations preclude growth in normal tissue but do not reduce bacterial virulence in tumor cells. The tumor-targeting strain of S. typhimurium, termed A1-R and expressing green...
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