Article
Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.
PloS one - 1 Jan 2014
Jeong Jae-Ho, Kim Kwangsoo, Lim Daejin, Jeong Kwangjoon, Hong Yeongjin, Nguyen Vu H, Kim Tae-Hyoung, Ryu Sangryeol, Lim Jeong-A, Kim Jae Il, Kim Geun-Joong, Kim Sun Chang, Min Jung-Joon, Choy Hyon E
Abstract excerpt
Bacterial cancer therapy relies on the fact that several bacterial species are capable of targeting tumor tissue and that bacteria can be genetically engineered to selectively deliver therapeutic proteins of interest to the targeted tumors. However, the challenge of bacterial cancer therapy is the release of the therapeutic proteins from the bacteria and entry of the proteins into tumor cells. This study employed...
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