Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Salmonella Typhimurium mutant strain capable of RNAi delivery: higher tumor-targeting and lower toxicity.

Cancer biology & therapy - 1 Aug 2014

Cheng Xiawei, Zhang Xiaoxin, Zhou Yuqiang, Zhang Chunmei, Hua Zi-Chun

Abstract excerpt

Bacteria are highly versatile and useful tools that could deliver short interfering RNA. In this study, a phoP/phoQ double-deleted Salmonella Typhimurium named VNP(PhoP/Q(-)) based on the genetic background of VNP20009. The biological safety and function of VNP(PhoP/Q(-)) were also analyzed. Our study revealed the following results: (1) VNP(PhoP/Q(-)) exhibited lower titers in tumor-free livers and spleens than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Vaccines
Share to Genetic Therapy
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Mammary Neoplasms, Animal

Share to RNA, Small Interfering

Share to Salmonella typhimurium

Share to Spleen

Source

Open in PubMed Open full text

Identifiers

PMID: 24842165
DOI: 10.4161/cbt.29185
PMCID: PMC4119074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Salmonella Typhimurium mutant strain capable of RNAi delivery: higher tumor-targeting and lower toxicity.PMID 24842165Read ↗

A self-lysed attenuated Salmonella platform with flagellar displaying mediates tumor therapySemantic proximity Read ↗

Anti-tumoral effect of the mitochondrial target domain of Noxa delivered by an engineered Salmonella typhimurium.Semantic proximity Read ↗

Innovative Bacterial Therapies and Genetic Engineering Approaches in Colorectal Cancer: A Review of Emerging Strategies and Clinical ImplicationsSemantic proximity Read ↗

Blockage of autophagy pathway enhances <i>Salmonella</i> tumor-targetingSemantic proximity Read ↗

Attenuated mutants of Salmonella enterica Typhimurium mediate melanoma regression via an immune response.Semantic proximity Read ↗

Development of Oxytolerant Salmonella typhimurium Using Radiation Mutation Technology (RMT) for Cancer Therapy.Semantic proximity Read ↗

Construction of Salmonella typhimurium sptP mutant and evaluation of its characterization and immunoprotective effectSemantic proximity Read ↗

The small RNA STnc1480 contributes to the regulation of biofilm formation and pathogenicity in Salmonella TyphimuriumSemantic proximity Read ↗

Exploration of Salmonella effector mutant strains on MTR4 and RRP6 degradation.Semantic proximity Read ↗

Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagySemantic proximity Read ↗

Enhanced bacterial cancer therapy delivering therapeutic RNA interference of c-Myc, a key driver of tumourigenesis.Semantic proximity Read ↗

Evaluation of Tumor-colonizing <i>Salmonella</i> Strains using the Chick Chorioallantoic Membrane ModelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.