Article
Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2007
Zhao Ming, Geller Jack, Ma Huaiyu, Yang Meng, Penman Sheldon, Hoffman Robert M
Abstract excerpt
Bacterial infection occasionally has a marked therapeutic effect on malignancies, as noted as early as the 19th century. Recently, there have been attempts to develop cancer treatment by using tumor-targeting bacteria. These treatments were developed to deliver therapeutic molecules specifically to tumors. Researchers used anaerobic microorganisms that preferentially grew in necrotic tumor areas. However, the...
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