Article
Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines.
Carcinogenesis - 1 Jul 1997
Macé K, Aguilar F, Wang J S, Vautravers P, Gómez-Lechón M, Gonzalez F J, Groopman J, Harris C C, Pfeifer A M
Abstract excerpt
Epidemiological evidence has been supporting a relationship between dietary aflatoxin B1 (AFB1) exposure, development of human primary hepatocellular carcinoma (HCC) and mutations in the p53 tumor suppressor gene. However, the correlation between the observed p53 mutations, the AFB1 DNA adducts and their activation pathways has not been elucidated. Development of relevant cellular in vitro models, taking into...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.