Article
Chemical and physical carcinogenesis: advances and perspectives for the 1990s.
Cancer research - 15 Sept 1991
Harris C C
Abstract excerpt
Carcinogenesis is a multistage process driven by carcinogen-induced genetic and epigenetic damage in susceptible cells that gain a selective growth advantage and undergo clonal expansion as the result of activation of protooncogenes and/or inactivation of tumor suppressor genes. Therefore, the mu...
Topics
- Animals
- Carcinogens
- DNA Damage
- DNA Repair
- Genes, Tumor Suppressor
- Humans
- Mutation
- Neoplasms
- Proto-Oncogenes
- Risk Factors