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Article

The Pro/Pro genotype of the p53 codon 72 polymorphism modulates PAI-1 plasma levels in ageing.

Mechanisms of ageing and development - 1 Aug 2009

Testa Roberto, Bonfigli Anna Rita, Salvioli Stefano, Invidia Laura, Pierini Michela, Sirolla Cristina, Marra Maurizio, Testa Ivano, Fazioli Francesca, Recchioni Rina, Marcheselli Fiorella, Olivieri Fabiola, Lanari Luigi, Franceschi Claudio

Abstract excerpt

Plasminogen activator inhibitor 1 (PAI-1) is over-expressed during ageing and it has been linked to cellular senescence. Recently, PAI-1 has been also identified in vitro as a critical downstream target of p53. TP53, the p53 gene, has a common functional polymorphism at codon 72 which influences...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19523975
DOI: 10.1016/j.mad.2009.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19523975-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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