Article
Influence of the TP53 codon 72 polymorphism on the cellular responses to X-irradiation in fibroblasts from nonagenarians.
Mechanisms of ageing and development - 1 Apr 2008
den Reijer P Martijn, Maier Andrea B, Westendorp Rudi G J, van Heemst Diana
Abstract excerpt
In mice, genetic modification of the gene encoding p53 affects both cancer incidence and longevity. In humans, we recently found that a TP53 codon 72 Arginine (Arg) to Proline (Pro) polymorphism affected both cancer incidence and longevity as well. The TP53 codon 72 polymorphism has previously been shown to influence the apoptotic potential of human cells in response to oxidative stress. Here, we studied the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.