Article
p53 codon 72 alleles influence the response to anticancer drugs in cells from aged people by regulating the cell cycle inhibitor p21WAF1.
Cell cycle (Georgetown, Tex.) - 1 Sept 2005
Salvioli Stefano, Bonafé Massimiliano, Barbi Cristiana, Storci Gianluca, Trapassi Chiara, Tocco Francesca, Gravina Silvia, Rossi Matteo, Tiberi Luca, Mondello Chiara, Monti Daniela, Franceschi Claudio
Abstract excerpt
A common polymorphism at codon 72 in p53 gene leads to an arginine to proline aminoacidic substitution which affects in an age-dependent manner the susceptibility of cells to undergo apoptosis after oxidative stress. Here we report that dermal fibroblasts from Proline allele carriers (Pro+) display a higher expression of p21WAF1 gene, in both basal conditions and after treatment with doxorubicin or camptothecin....
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