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Article

Variation in the human TP53 gene affects old age survival and cancer mortality.

Experimental gerontology - 1 Jan 2000

van Heemst Diana, Mooijaart Simon P, Beekman Marian, Schreuder Jeroen, de Craen Anton J M, Brandt Bernd W, Slagboom P Eline, Westendorp Rudi G J

Abstract excerpt

Longevity may depend on a balance between tumor suppression and tissue renewal mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5), 339-349]. Mice with constitutively activated p53 are almost cancer free but their life span is reduced and accompanied by early ti...

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Identifiers

PMID: 15732191
DOI: 10.1016/j.exger.2004.10.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15732191-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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