Article
Variation in the human TP53 gene affects old age survival and cancer mortality.
Experimental gerontology - 1 Jan 2000
van Heemst Diana, Mooijaart Simon P, Beekman Marian, Schreuder Jeroen, de Craen Anton J M, Brandt Bernd W, Slagboom P Eline, Westendorp Rudi G J
Abstract excerpt
Longevity may depend on a balance between tumor suppression and tissue renewal mechanisms [Campisi, J., 2003. Cancer and ageing: rival demons? Nat. Rev. Cancer 3 (5), 339-349]. Mice with constitutively activated p53 are almost cancer free but their life span is reduced and accompanied by early tissue atrophy [Tyner et al., 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (6867)...
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