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Article

Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population.

The Journal of experimental medicine - 11 Jun 2007

Ørsted David Dynnes, Bojesen Stig Egil, Tybjaerg-Hansen Anne, Nordestgaard Børge Grønne

Abstract excerpt

p53 is an important tumor suppressor, normally preventing cancer development via apoptosis. A genomic Arg72Pro substitution in the p53 protein has important influence on cell death via apoptosis, which could be beneficial. We therefore tested the hypotheses that this polymorphism influences longevity, survival after a cancer diagnosis, and risk of cancer in the general population. We examined a cohort of 9,219...

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Identifiers

PMID: 17535973
DOI: 10.1084/jem.20062476
PMCID: PMC2118619

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