Article
The common germline Arg72Pro polymorphism of p53 and increased longevity in humans.
Cell cycle (Georgetown, Tex.) - 15 Jan 2008
Bojesen Stig E, Nordestgaard Børge G
Abstract excerpt
More than ten million single nucleotide polymorphisms (SNPs) have been identified in humans; however, the importance of most SNPs for health and disease is not understood. Most SNPs are indeed unimportant and because of often inadequately powered studies, many observations on SNP effects can not be repeated by other researchers. SNPs are at best shown to influence protein function or level, rarely to influence...
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