The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

doi:10.1186/1471-2350-10-56

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Article

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.

BMC medical genetics - 12 Jun 2009

Bressler Jan, Fornage Myriam, Hanis Craig L, Kao Wen Hong Linda, Lewis Cora E, McPherson Ruth, Dent Robert, Mosley Thomas H, Pennacchio Len A, Boerwinkle Eric

Abstract excerpt

BACKGROUND: In a genome-wide association study performed in the Framingham Offspring Cohort, individuals homozygous for the rs7566605 C allele located upstream of insulin-induced gene 2 (INSIG2) were reported to incur an increased risk of obesity. This finding was later replicated in four out of five populations examined. The goal of the study reported here was to assess the role of the INSIG2 single nucleotide...

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Identifiers

PMID: 19523229
DOI: 10.1186/1471-2350-10-56
PMCID: PMC2706232

Genes

INSIG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.PMID 19523229Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

INSIG-2 promoter polymorphism and obesity related phenotypes: association study in 1428 members of 248 families.Semantic proximity Read ↗

Absence of association between the INSIG2 gene polymorphism (rs7566605) and obesity in the European Youth Heart Study (EYHS).Semantic proximity Read ↗

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.Semantic proximity Read ↗

No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits.Semantic proximity Read ↗

INSIG2 gene polymorphism is not associated with obesity in Caucasian, Afro-Caribbean and Indian subjects.Semantic proximity Read ↗

INSIG2 polymorphism is neither associated with BMI nor with phenotypes of lipoprotein metabolism.Semantic proximity Read ↗

A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.Semantic proximity Read ↗

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.Semantic proximity Read ↗

The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.Semantic proximity Read ↗

Comment on "A common genetic variant is associated with adult and childhood obesity".Semantic proximity Read ↗

No association between INSIG2 Gene rs7566605 polymorphism and being overweight in Japanese population.Semantic proximity Read ↗

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