A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.

doi:10.1186/1471-2350-10-143

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Article

A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.

BMC medical genetics - 22 Dec 2009

Deka Ranjan, Xu Ling, Pal Prodipto, Toelupe Palanitina T, Laumoli Tuiasina S, Xi Huifeng, Zhang Ge, Weeks Daniel E, McGarvey Stephen T

Abstract excerpt

BACKGROUND: A genome wide association study found significant association of a sequence variant, rs7566605, in the insulin-induced gene 2 (INSIG2) with obesity. However, the association remained inconclusive in follow-up studies. We tested for association of four tagging SNPs (tagSNPs) including this variant with body mass index (BMI) and abdominal circumference (ABDCIR) in the Samoans of the Western Pacific, a...

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PMID: 20028541
DOI: 10.1186/1471-2350-10-143
PMCID: PMC2804583

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INSIG2

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Related research

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Research trail→

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A tagging SNP in INSIG2 is associated with obesity-related phenotypes among Samoans.PMID 20028541Read ↗

The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts.Semantic proximity Read ↗

Genetic associations of the INSIG2 rs7566605 polymorphism with obesity-related metabolic traits in Malaysian Malays.Semantic proximity Read ↗

A whole genome linkage scan identifies multiple chromosomal regions influencing adiposity-related traits among Samoans.Semantic proximity Read ↗

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese.Semantic proximity Read ↗

Association of the common genetic variant upstream of INSIG2 gene with obesity related phenotypes in Chinese children and adolescents.Semantic proximity Read ↗

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations.Semantic proximity Read ↗

INSIG2 variants, dietary patterns and metabolic risk in Samoa.Semantic proximity Read ↗

A common genetic variant is associated with adult and childhood obesity.Semantic proximity Read ↗

The common genetic variant upstream of INSIG2 gene is not associated with obesity in Indian population.Semantic proximity Read ↗

Prevalence of adiposity and associated cardiometabolic risk factors in the Samoan genome-wide association study.Semantic proximity Read ↗

INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Semantic proximity Read ↗

The single nucleotide polymorphism upstream of insulin-induced gene 2 ( INSIG2) is associated with the prevalence of hypercholesterolaemia, but not with obesity, in Japanese American women.Semantic proximity Read ↗

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