Article
The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.
PLoS genetics - 27 Apr 2007
Lyon Helen N, Emilsson Valur, Hinney Anke, Heid Iris M, Lasky-Su Jessica, Zhu Xiaofeng, Thorleifsson Gudmar, Gunnarsdottir Steinunn, Walters G Bragi, Thorsteinsdottir Unnur, Kong Augustine, Gulcher Jeffrey, Nguyen Thuy Trang, Scherag André, Pfeufer Arne, Meitinger Thomas, Brönner Günter, Rief Winfried, Soto-Quiros Manuel E, Avila Lydiana, Klanderman Barbara, Raby Benjamin A, Silverman Edwin K, Weiss Scott T, Laird Nan, Ding Xiao, Groop Leif, Tuomi Tiinamaija, Isomaa Bo, Bengtsson Kristina, Butler Johannah L, Cooper Richard S, Fox Caroline S, O'Donnell Christopher J, Vollmert Caren, Celedón Juan C, Wichmann H Erich, Hebebrand Johannes, Stefansson Kari, Lange Christoph, Hirschhorn Joel N
Abstract excerpt
A SNP upstream of the INSIG2 gene, rs7566605, was recently found to be associated with obesity as measured by body mass index (BMI) by Herbert and colleagues. The association between increased BMI and homozygosity for the minor allele was first observed in data from a genome-wide association scan of 86,604 SNPs in 923 related individuals from the Framingham Heart Study offspring cohort. The association was...
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